Meiosis featured

Meiosis: Definition, Prophase, Metaphase & Significance of Meiosis

Abstract About Meiosis

Meiosis is the characteristic event of sexual reproduction that results in the reduction of chromosomes in daughter cells as compared to parent cells. Meiosis includes two rounds of division. The first one is the reduction and the second is just like mitotic division.

The new daughter cells formed are haploid. The prophase of meiosis is also significant because it has some important events. Crossing over – the reshuffling of genetic material (chromosomes) takes place which produces new recombinants and causes genetic diversity. It occurs in animals at the time of gamete formation and in plants at the time of spore formation.

In meiosis I there is segregation of paired chromosomes and at the end, each daughter cell contains one chromosome (with two chromatids). Meiosis II is the second meiotic division, that involves equational partition, or separation of sister chromatids. Mechanically, the process resembles mitosis, though its outcomes are different.

The completion result is the production of four haploid cells. Meiosis is significant for variation produces by crossing over and a random assortment of chromosomes. Secondly, maintains the number of chromosomes constant in species. If there is no meiosis the chromosome number will become double after every generation.

The word meiosis originates from the Greek word ‘meioun’, meaning “to make small,” as it results in a reduction in chromosome number. Meiosis was first discovered and described by German biologist OscarHertwig in sea urchin eggs in 1876.

Definition of Meiosis

Meiosis is a special kind of cellular division in which the number of chromosomes in daughter cells is reduced to half, as compared to the parent cell. In animals at the time of gamete formation, while in plants when spores are generated.

Each diploid cell after meiosis produces 4 haploid cells, due to the fact that it involves two consecutive divisions after single replication of DNA. Two divisions are meiosis I and meiosis II. The initial meiotic division is the reduction division, whereas the second meiotic department is just like the mitosis.

Both divisions are divided into subphases like prophase 1, metaphase 1, anaphase 1, telophase 1, and the very same names are used for phases of meiosis II.

The preparatory steps of meiosis are identical to the interphase of mitosis. Interphase is divided into the same three phases i.e. G1, S phase, and G2. Interphase is followed by meiosis I and meiosis II.

Phases of Meiosis

Prophase I

This is a long phase, and differs from the prophase of mitosis, because in this, chromosomes behave as homologous pairs. Each diploid cell has two chromosomes of each type, one participant from each parent, as a result of the fusion of male and female gametes. Each chromosome has two chromatids because chromosomes have been replicated during interphase. The interphase of meiosis lacks the G2 phase. These similar but not necessarily similar chromosomes are called homologous chromosomes.

Prophase I further consists of the following stages.

Leptotene:

The chromosomes become shorten and thick so they become visible. The size of the nucleus increases and homologous chromosomes start getting closer to each other.

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Zygotene:

The pairing of homologous chromosomes starts during zygotene. It is called synapsis. It is the first vital phenomenon of meiosis. This pairing is highly specific. Exact point-to-point pairing takes place. But this pairing has no definite starting point. Each paired but not fused complex structure is called a bivalent or tetrad.

Pachytene (packing):

The pairing of homologous chromosomes is completed. Chromosomes become thicker and thicker. Each bivalent has four chromatids. These chromatids wrap around each other. Non-sister chromatids of homologous chromosomes exchange their segments by chiasmata formation during crossing over.

The exchange of segments of the non-sister chromatids of homologous chromosomes is called crossing over. Thus, the reshuffling of genetic material takes place. Crossing over produces new recombination. Pachytene may last for days, weeks, or even years but leptotene and zygotene can last only for a few hours.

Meiosis Pachytene

Diplotene: 

The paired chromosomes repel each other. So, they begin to separate from each other. The homologous chromosomes remain united by chiasmata. So, separation is not complete. Each bivalent has at least one chiasmata. Otherwise, the chromatids can separate from each other.

Diakinesis: 

The condensation of chromosomes reaches its maximum point during this phase. At the same time separation of the homologous chromosomes is completed. But still, they are united at one point at the end not by chiasmata. The nucleoli disappear.

Meiosis-3

Metaphase I

The nuclear membrane disorganizes at the beginning of this stage. Spindle fibers originate and the kinetochore fibers connect to the kinetochore of the homologous chromosome from each pole and organize bivalents at the equator. The sister chromatids of a specific chromosome in the bivalent act as a single unit.

Anaphase I

The kinetochore fibers contract and the spindle or pole fibers lengthen, which pull the single chromosome (each having 2 chromatids) towards their particular poles. It may be kept in mind here that in contrast to anaphase of mitosis, sister chromatids are not separated. This is actually a reduction phase because each pole gets half of the overall number of chromosomes.

Telophase I

The nuclear membrane rearranges around each set of chromosomes at both poles, nucleoli reappear thus two nuclei each with half the number of chromosomes are formed. Afterward, the cytoplasm divides thus ending the first meiotic division. It is also to be kept in mind that chromosomes might decondense in this phase.

Meiosis II

Meiosis II is the second meiotic division, and normally involves equational partition, or separation of sister chromatids. Mechanically, the process resembles mitosis, though its outcomes are different. The completion result is the production of four haploid cells (n chromosomes, 23 in humans) from the two haploid cells (with n chromosomes, each including two sister chromatids) produced in meiosis I. The four main steps of meiosis II are: prophase II, metaphase II, anaphase II, and telophase II.

Prophase II, metaphase II, anaphase II, and telophase II are similar to the particular phases of mitosis throughout which the chromosomes, condense, mitotic apparatus (spindle fibers) form, chromosomes set up at the equator, individual/sister chromatids move apart, and eventually, four nuclei at the respective poles of two daughter cells (formed after meiosis I) are formed.

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Meiosis-4

Cytokinesis occurs and four haploid cells, with half of the number of chromosomes (chromatids), are formed. Meiosis is now total and winds up with four new haploid daughter cells.

Significance of Meiosis
  • Variations:

Two significant process take place during meiosis. These are:

  1. Crossing over: The parental chromosome exchange segments with each other during crossing over others. It results in a large number of recombination.
  2. Random assortment of chromosomes: The separation of homologous chromosomes is random during anaphase. It gives a large variety of gametes.

Both these phenomenon cause variations and modifications in the genome. These variations are the base of evolution. These variations also make every individual-specific, particular and unique in his characteristics. Even the progeny of very same parent i.e. brothers and sisters are not identical to each other.

  • A constant number of chromosomes in each generation:

Meiosis takes place during gamete formation and spore formation in plants. Thus, it reduces the number of chromosomes to one half in each gamete or spore. The original number of chromosomes is restored after fertilization. So, it maintains the chromosome number of constant generation after generation. If there is no meiosis the chromosome number will become double after every generation.

FAQs about Meiosis

1. What is Meiosis?

  • Meiosis is a specialized form of cellular division that reduces the number of chromosomes in daughter cells by half compared to the parent cell. It occurs during gamete formation in animals and spore generation in plants.

2. How many cells does a diploid cell produce after meiosis?

  • A diploid cell produces four haploid cells after meiosis, each containing half the number of chromosomes of the parent cell.

3. What are the phases of Meiosis I?

  • Meiosis I includes prophase I, metaphase I, anaphase I, and telophase I. These stages involve the pairing of homologous chromosomes, crossing over, and the reduction of chromosome number.

4. What is crossing over, and when does it occur?

  • Crossing over is the exchange of genetic segments between non-sister chromatids of homologous chromosomes. It occurs during prophase I of meiosis.

5. How does Meiosis II differ from Meiosis I?

  • Meiosis II is the second meiotic division, resembling mitosis, and involves the separation of sister chromatids. It results in the production of four haploid cells from the two haploid cells produced in Meiosis I.

6. What is the significance of Meiosis?

  • Meiosis introduces genetic variations through processes like crossing over and random assortment of chromosomes. It ensures a constant number of chromosomes in each generation and is crucial for evolution and individual uniqueness.

7. Why is Meiosis important in gamete formation?

  • Meiosis reduces the chromosome number in gametes, ensuring that the original chromosome number is restored after fertilization. Without meiosis, the chromosome number would double in each generation.

8. How long does Meiosis take, and what are the preparatory steps?

  • Meiosis involves interphase, which is divided into G1, S phase, and G2, similar to mitosis. The actual meiotic divisions (Meiosis I and Meiosis II) follow interphase and can vary in duration.

9. Can you explain the phases of Prophase I in Meiosis?

  • Prophase I is a lengthy phase consisting of Leptotene, Zygotene, Pachytene, Diplotene, and Diakinesis. It involves the pairing of homologous chromosomes, crossing over, and condensation of chromosomes.
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10. How does Meiosis contribute to genetic diversity?

Meiosis contributes to genetic diversity through crossing over and the random assortment of chromosomes. These processes lead to variations in the genetic makeup of gametes, making each individual unique.

Summary: Meiosis

Meiosis is a specialized form of cellular division crucial for sexual reproduction, occurring during gamete formation in animals and spore generation in plants. It involves two consecutive divisions—Meiosis I and Meiosis II—resulting in the production of four haploid cells from a single diploid cell. The process introduces genetic variations through crossing over during Prophase I and the random assortment of chromosomes during Anaphase I.

The preparatory steps of meiosis are similar to mitosis, involving interphase with G1, S phase, and G2 phases. Prophase I, a crucial stage, includes Leptotene, Zygotene, Pachytene, Diplotene, and Diakinesis, featuring the pairing of homologous chromosomes and crossing over.

Meiosis I comprises distinct stages—Prophase I, Metaphase I, Anaphase I, and Telophase I—leading to the reduction of chromosome number. Meiosis II, resembling mitosis, involves Prophase II, Metaphase II, Anaphase II, and Telophase II, resulting in the production of four haploid cells.

The significance of meiosis lies in maintaining a constant number of chromosomes across generations, introducing genetic variations, and ensuring individual uniqueness. FAQs cover essential aspects, such as the phases of Meiosis I, the significance of crossing over, and the contribution of meiosis to genetic diversity. Overall, meiosis is a fundamental process vital for the continuity of life and the diversity of living organisms.